KRT1

Across TCGA pan-cancer cohorts, KRT1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated KRT1 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher KRT1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRT1 expression acts as an unfavorable survival marker.

KICH, HNSC, and LUAD are the cancer types where KRT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.035	0.904	<.001	30	view →
HNSC	DFS	Median	All	0.140	0.604	.001	20	view →
LUAD	OS	Median	II,III,IV	0.147	0.682	<.001	12	view →
LIHC	OS	Median	All	0.105	0.774	.002	12	view →
LGG	DFS	Median	All	0.172	0.845	<.001	8	view →
SKCM	OS	Median	III,IV	0.295	0.737	.001	6	view →
SARC	OS	Median	All	0.162	0.767	.002	3	view →
SCLC	OS	Median	All	0.315	0.655	.041	3	view →
COAD	OS	Median	II,III,IV	0.689	0.857	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

KRT1–KICH (DFS)

Open the KICH breakdown →