KRT1

Across TCGA patient cohorts, KRT1 mutation is significantly associated with the RNA expression of many other genes, with 3,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT1-associated genes across cancer lineages are SH3GL1, HMG20B, and MRPL37. Each is linked with KRT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KRT1-to-partner and partner-to-KRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL1 grouped by KRT1-low versus KRT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT1→partner) and Y-score (partner→KRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SH3GL1 →	+0.401	+3.032	<.001	<.001	3	4
SKCM	HMG20B →	+0.572	+1.671	<.001	.003	3	4
UCEC	MRPL37 →	+0.399	+2.440	.002	<.001	3	4
LUAD	RITA1 →	+0.658	+3.643	<.001	.001	3	4
STAD	TTTY9B →	+0.048	+4.633	<.001	<.001	3	3
SKCM	QPCTL →	+0.606	+2.738	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,015 associations by consensus.

SH3GL1 by KRT1 expression — UCEC

Explore this box plot interactively →