KRT1

Across TCGA cell cohorts, KRT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 853 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KRT1-associated GO terms across cancer lineages are Regulation of cap-dependent translational initiation, Positive regulation of cap-dependent translational initiation, and Regulation of cap-independent translational initiation. Each is linked with KRT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT1-to-partner and partner-to-KRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cap-dependent translational initiation grouped by KRT1-low versus KRT1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT1→partner) and Y-score (partner→KRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of cap-dependent translational initiation →	+0.105	+1.450	<.001	<.001	3	3
BLOOD_Leukemia	Positive regulation of cap-dependent translational initiation →	+0.105	+1.450	<.001	<.001	3	3
BLOOD_Leukemia	Regulation of cap-independent translational initiation →	+0.107	+1.454	<.001	<.001	3	3
BLOOD_Leukemia	Positive regulation of cap-independent translational initiation →	+0.107	+1.454	<.001	<.001	3	3
BLOOD_Leukemia	Regulation of stem cell differentiation →	+0.063	+1.081	<.001	.003	3	3
BLOOD_Leukemia	Negative regulation of stem cell differentiation →	+0.102	+1.168	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 853 associations by consensus.

Regulation of cap-dependent translational initiation by KRT1 expression — BLOOD_Leukemia

Explore this box plot interactively →