KRT1

Across TCGA cell cohorts, KRT1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,354 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible KRT1-associated genes across cancer lineages are PGAM5, TMEM69, and RAB20. Each is linked with KRT1 in more than 5 cancer types. Because this analysis shows association rather than direction, both KRT1-to-partner and partner-to-KRT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KRT1 versus PGAM5 in UPPER_AERODIGESTIVE_TRACT, with a Pearson correlation of -0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT1→partner) and Y-score (partner→KRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PGAM5 →	-1.367	-1.449	<.001	.008	3	6
UPPER_AERODIGESTIVE_TRACT	TMEM69 →	-1.168	-1.540	<.001	.008	3	6
BLOOD_Lymphoma	RAB20 →	+1.742	+0.633	.003	.006	3	5
BLOOD_Lymphoma	PXDC1 →	+1.836	+0.797	.006	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	DHODH →	-0.762	-1.563	.007	.008	3	5
BONE	POLR1B →	-0.934	-1.676	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,354 associations by consensus.

KRT1 vs PGAM5 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →