KRT1

Across TCGA cell cohorts, KRT1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KRT1-associated genes across cancer lineages are C3orf56, MMP27, and SLC35G3. Each is linked with KRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT1-to-partner and partner-to-KRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C3orf56 grouped by KRT1-low versus KRT1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT1→partner) and Y-score (partner→KRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C3orf56 →	+0.003	+4.078	<.001	.009	3	2
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	SLC35G3 →	+0.028	+3.874	.005	.005	3	1
BLOOD_Leukemia	GPR101 →	+0.055	+3.551	.007	.009	3	1
BLOOD_Leukemia	MAGEC3 →	+0.318	+3.855	<.001	.007	3	1
BLOOD_Leukemia	INSM2 →	+0.184	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

C3orf56 by KRT1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →