KRIT1

Across TCGA pan-cancer cohorts, KRIT1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KRIT1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher KRIT1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated KRIT1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

BLCA, LUAD, and LUSC are the cancer types where KRIT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	1.000	0.406	.007	21	view →
LUAD	OS	Median	All	0.279	0.813	<.001	12	view →
LUSC	OS	Median	III,IV	0.178	0.663	.044	3	view →
SKCM	DFS	Median	II,III,IV	1.000	0.682	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KRIT1–BLCA (OS)

Open the BLCA breakdown →