KRIT1

Across TCGA cell cohorts, KRIT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,652 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KRIT1-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Pre-mRNA catabolic process, and Viral translational termination-reinitiation. Each is linked with KRIT1 in more than 16 cancer types. Because this analysis shows association rather than direction, both KRIT1-to-partner and partner-to-KRIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by KRIT1-low versus KRIT1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRIT1→partner) and Y-score (partner→KRIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of isotype switching to IgG isotypes →	+0.129	+0.950	<.001	<.001	3	17
STOMACH	Pre-mRNA catabolic process →	+0.172	+0.963	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.102	+1.134	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.090	-0.829	<.001	<.001	3	14
LARGE_INTESTINE	Establishment of protein localization to vacuole →	+0.059	+0.534	.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.085	+1.370	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,652 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by KRIT1 expression — SOFT_TISSUE

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