KRIT1

Across TCGA cell cohorts, KRIT1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRIT1-associated genes across cancer lineages are FCN2, MAGEB4, and HTN1. Each is linked with KRIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRIT1-to-partner and partner-to-KRIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by KRIT1-low versus KRIT1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRIT1→partner) and Y-score (partner→KRIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FCN2 →	+0.048	+4.714	<.001	.002	3	2
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	HTN1 →	+0.217	+3.103	<.001	.004	3	1
LARGE_INTESTINE	CCDC54 →	+0.149	+3.736	<.001	.004	3	1
LARGE_INTESTINE	TMEFF2 →	+0.196	+3.333	.001	.009	3	1
LARGE_INTESTINE	ZAN →	+0.010	+3.297	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

FCN2 by KRIT1 expression — BLOOD_Lymphoma

Explore this box plot interactively →