KRI1

Across TCGA pan-cancer cohorts, KRI1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KRI1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRI1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRI1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where KRI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.480	0.833	<.001	50	view →
CCRCC	DFS	Quartile	All	0.600	0.933	<.001	45	view →
LSCC	DFS	Quartile	II,III,IV	0.939	0.464	.001	41	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.888	.024	18	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
LUAD	OS	Median	All	0.786	0.969	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KRI1–HNSC (DFS)

Open the HNSC breakdown →