KRI1

Across TCGA patient cohorts, KRI1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRI1-associated genes across cancer lineages are ERK2, PKC-a_pS657, and ATM. Each is linked with KRI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRI1-to-partner and partner-to-KRI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by KRI1-low versus KRI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRI1→partner) and Y-score (partner→KRI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.239	+2.415	<.001	.003	3	2
UCEC	PKC-a_pS657 →	-0.294	-2.105	.040	.017	3	2
UCEC	ATM →	-0.643	-2.893	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.486	+1.874	.029	.049	3	2
UCEC	EGFR_pY1068 →	-0.221	-1.765	.018	.014	3	1
UCEC	INPP4B →	-0.266	-1.874	.028	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ERK2 by KRI1 expression — UCEC

Explore this box plot interactively →