KREMEN2

Across TCGA cell cohorts, KREMEN2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KREMEN2-associated genes across cancer lineages are OR10A4, TRARG1, and EPPIN. Each is linked with KREMEN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KREMEN2-to-partner and partner-to-KREMEN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A4 grouped by KREMEN2-low versus KREMEN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KREMEN2→partner) and Y-score (partner→KREMEN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10A4 →	+0.045	+2.938	.007	.007	3	1
LARGE_INTESTINE	TRARG1 →	+0.021	+3.760	<.001	<.001	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	CFC1 →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR10A4 by KREMEN2 expression — LARGE_INTESTINE

Explore this box plot interactively →