KRCC1

Across TCGA patient cohorts, KRCC1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRCC1-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR, and eIF4E. Each is linked with KRCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRCC1-to-partner and partner-to-KRCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KRCC1-low versus KRCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRCC1→partner) and Y-score (partner→KRCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.766	+3.189	.010	.010	3	2
UCEC	EGFR →	-0.232	-2.321	.003	.035	3	1
UCEC	eIF4E →	+0.245	+3.459	.020	.005	3	1
UCEC	MEK1 →	+0.405	+2.321	.027	.035	3	1
UCEC	MSH2 →	-0.383	-3.459	<.001	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.287	+3.472	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Caspase-7-cleavedD198 by KRCC1 expression — UCEC

Explore this box plot interactively →