KRBOX4

Across TCGA patient cohorts, KRBOX4 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRBOX4-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with KRBOX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRBOX4-to-partner and partner-to-KRBOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by KRBOX4-low versus KRBOX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRBOX4→partner) and Y-score (partner→KRBOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.113	-1.664	.003	.023	3	1
UCEC	EGFR_pY1068 →	-0.293	-2.584	.002	.001	3	1
UCEC	A-Raf_pS299 →	-0.133	-3.459	.003	.005	3	1
UCEC	ERK2 →	+0.238	+2.087	.001	.005	3	1
UCEC	GATA6 →	-0.176	-2.314	.005	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.161	-2.000	.013	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

14-3-3_beta by KRBOX4 expression — UCEC

Explore this box plot interactively →