KRBA1

Across TCGA patient cohorts, KRBA1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRBA1-associated genes across cancer lineages are DJ-1, c-Met, and EGFR. Each is linked with KRBA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRBA1-to-partner and partner-to-KRBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DJ-1 grouped by KRBA1-low versus KRBA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRBA1→partner) and Y-score (partner→KRBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DJ-1 →	+0.233	+3.178	.010	.010	3	3
LUSC	c-Met →	+0.749	+2.853	<.001	.034	3	2
UCEC	EGFR →	-0.177	-3.558	<.001	.002	3	2
UCEC	INPP4B →	-0.252	-1.678	.020	.021	3	2
UCEC	Notch1 →	+0.105	+1.331	.026	.043	3	2
UCEC	PDCD4 →	-0.516	-1.874	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

DJ-1 by KRBA1 expression — COAD

Explore this box plot interactively →