KRBA1

Across TCGA cell cohorts, KRBA1 mutation is significantly associated with the RNA expression of many other genes, with 311 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRBA1-associated genes across cancer lineages are GFRA4, OR10K2, and OR10T2. Each is linked with KRBA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRBA1-to-partner and partner-to-KRBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by KRBA1-low versus KRBA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRBA1→partner) and Y-score (partner→KRBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GFRA4 →	+0.272	+4.824	.001	<.001	3	2
BLOOD_Leukemia	OR10K2 →	+0.053	+5.121	<.001	<.001	3	2
BLOOD_Leukemia	OR10T2 →	+1.016	+4.691	<.001	<.001	3	2
LARGE_INTESTINE	SPATA4 →	+0.126	+2.537	.002	.008	3	2
OESOPHAGUS	MS4A14 →	+0.053	+4.906	<.001	.006	3	1
OESOPHAGUS	SPINK8 →	+0.263	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 311 associations by consensus.

GFRA4 by KRBA1 expression — BLOOD_Leukemia

Explore this box plot interactively →