KPTN

Across TCGA pan-cancer cohorts, KPTN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KPTN data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KPTN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KPTN expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where KPTN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.850	0.568	<.001	90	view →
LUAD	DFS	Median	II,III,IV	0.716	0.969	.002	33	view →
CCRCC	DFS	Tertile	III,IV	0.846	0.487	.007	23	view →
PDAC	OS	Median	III,IV	0.677	0.957	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KPTN–HNSC (OS)

Open the HNSC breakdown →