KPTN

Across TCGA patient cohorts, KPTN protein abundance is significantly associated with the RNA expression of many other genes, with 2,814 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible KPTN-associated genes across cancer lineages are C14orf132, NMRK1, and CD274. Each is linked with KPTN in more than 2 cancer types. Because this analysis shows association rather than direction, both KPTN-to-partner and partner-to-KPTN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KPTN versus C14orf132 in LSCC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPTN→partner) and Y-score (partner→KPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C14orf132 →	+0.649	+0.249	.001	<.001	3	3
OV	NMRK1 →	-0.584	-0.410	.001	<.001	3	2
OV	CD274 →	-0.729	-0.323	.001	.003	3	2
LSCC	CARNMT1 →	-0.584	-0.270	<.001	<.001	3	2
OV	FBP1 →	-0.918	-0.446	.006	.002	3	2
LSCC	MAPK8IP1P2 →	+0.833	+0.188	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,814 associations by consensus.

KPTN vs C14orf132 — LSCC

Explore this scatter interactively →