KPTN

Across TCGA patient cohorts, KPTN mutation is significantly associated with the RNA expression of many other genes, with 843 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPTN-associated genes across cancer lineages are RNU7-30P, RNU6-1212P, and MIR1343. Each is linked with KPTN in more than 1 cancer types. Because this analysis shows association rather than direction, both KPTN-to-partner and partner-to-KPTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-30P grouped by KPTN-low versus KPTN-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPTN→partner) and Y-score (partner→KPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU7-30P →	+0.425	+4.578	<.001	.008	3	2
HNSC	RNU6-1212P →	+0.353	+6.132	<.001	.001	3	2
COAD	MIR1343 →	+0.401	+5.003	.002	.004	3	2
UCEC	RN7SKP232 →	+0.108	+2.433	.006	.009	3	2
UCEC	RN7SKP12 →	+0.324	+3.288	<.001	<.001	3	2
LUAD	IGLJ4 →	+0.722	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 843 associations by consensus.

RNU7-30P by KPTN expression — HNSC

Explore this box plot interactively →