KPNB1

Across TCGA pan-cancer cohorts, KPNB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KPNB1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KPNB1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KPNB1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where KPNB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.527	1.000	.001	58	view →
LSCC	DFS	Tertile	II,III,IV	0.907	0.434	<.001	34	view →
PDAC	DFS	Median	III,IV	0.424	0.888	.001	14	view →
LUAD	OS	Median	II,III,IV	0.342	0.837	.019	12	view →
COAD	DFS	Median	III,IV	1.000	0.846	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KPNB1–CCRCC (OS)

Open the CCRCC breakdown →