KPNB1

Across TCGA cell cohorts, KPNB1 mutation is significantly associated with the RNA expression of many other genes, with 654 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KPNB1-associated genes across cancer lineages are FUT5, R3HDML, and GFRA4. Each is linked with KPNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNB1-to-partner and partner-to-KPNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FUT5 grouped by KPNB1-low versus KPNB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNB1→partner) and Y-score (partner→KPNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FUT5 →	+0.019	+2.183	<.001	.007	3	2
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Leukemia	GFRA4 →	+0.259	+4.824	.002	<.001	3	1
BLOOD_Leukemia	BTBD16 →	+0.063	+3.959	.004	.005	3	1
BLOOD_Leukemia	CYP39A1 →	+0.223	+3.769	<.001	.008	3	1
BLOOD_Leukemia	NPFFR1 →	+0.019	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 654 associations by consensus.

FUT5 by KPNB1 expression — LARGE_INTESTINE

Explore this box plot interactively →