Across TCGA patient cohorts, KPNA7 mutation is significantly associated with the RNA expression of many other genes, with 1,886 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPNA7-associated genes across cancer lineages are ABHD3, CTLA4, and TIMM22. Each is linked with KPNA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA7-to-partner and partner-to-KPNA7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA7→partner) and Y-score (partner→KPNA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABHD3 →	+0.746	+3.010	<.001	<.001	3	2
UCEC	CTLA4 →	+0.843	+2.600	.001	.006	3	2
UCEC	TIMM22 →	+0.377	+3.691	.004	.001	3	2
UCEC	MSR1 →	+0.823	+2.748	<.001	.003	3	2
UCEC	FECH →	+0.834	+3.459	<.001	.005	3	2
UCEC	ME2 →	+0.531	+2.332	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,886 associations by consensus.

Exploration

KPNA7 survival (RNA) · tumor vs normal (RNA) · all KPNA7 data types