Across TCGA patient cohorts, KPNA7 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPNA7-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and Tuberin. Each is linked with KPNA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA7-to-partner and partner-to-KPNA7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA7→partner) and Y-score (partner→KPNA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.858	+3.019	.001	.019	3	2
UCEC	MEK1 →	+0.455	+3.321	.007	.010	3	1
UCEC	Tuberin →	+0.393	+3.331	.001	.005	3	1
UCEC	YB-1_pS102 →	-0.174	-2.584	.043	.011	3	1
UCEC	eIF4E →	+0.264	+3.700	.007	.001	2	1
UCEC	p62 Lck ligand →	+0.733	+3.469	<.001	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

KPNA7 survival (RNA) · tumor vs normal (RNA) · all KPNA7 data types