KPNA6

Across TCGA pan-cancer cohorts, KPNA6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KPNA6 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KPNA6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KPNA6 expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

CCRCC, LUAD, and COAD are the cancer types where KPNA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.574	1.000	.005	40	view →
LUAD	DFS	Quartile	All	0.433	0.786	.013	11	view →
COAD	DFS	Median	III,IV	1.000	0.838	.036	6	view →
HNSC	DFS	Median	II,III,IV	0.842	0.707	.032	4	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
LSCC	DFS	Quartile	II,III,IV	0.890	0.546	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KPNA6–CCRCC (DFS)

Open the CCRCC breakdown →