Across TCGA pan-cancer cohorts, KPNA4 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated KPNA4 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.
The strongest signal is observed in thymoma (THYM), where higher KPNA4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KPNA4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
THYM, LIHC, and KIRP are the cancer types where KPNA4 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.