KPNA4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, KPNA4 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPNA4-associated genes across cancer lineages are eIF4E, FoxM1, and GATA6. Each is linked with KPNA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA4-to-partner and partner-to-KPNA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA4→partner) and Y-score (partner→KPNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeIF4E →+0.197+1.954.001<.00132
UCECFoxM1 →+0.147+1.347.048.00632
UCECGATA6 →-0.101-1.792.027.02332
UCECmTOR_pS2448 →-0.144-2.234<.001.00132
UCECPCNA →+0.274+2.765<.001<.00132
UCECRad50 →-0.140-1.347.045.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Exploration