KPNA3

Across TCGA pan-cancer cohorts, KPNA3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KPNA3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KPNA3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types KPNA3 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, CCRCC, and OV are the cancer types where KPNA3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KPNA3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.184	.008	4	view →
CCRCC	All	All	+0.063	.004	3	view →
OV	All	All	+0.363	.023	2	view →
PDAC	Male	All	+0.227	.006	2	view →
COAD	Female	III,IV	+0.191	.009	2	view →
LSCC	Male	All	+0.066	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KPNA3–HNSC

Open the HNSC breakdown →