KPNA3

Across TCGA cell cohorts, KPNA3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KPNA3-associated genes across cancer lineages are OR6K3, C8B, and OR5M11. Each is linked with KPNA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA3-to-partner and partner-to-KPNA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6K3 grouped by KPNA3-low versus KPNA3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA3→partner) and Y-score (partner→KPNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6K3 →	+0.030	+4.467	<.001	.004	3	1
SKIN	C8B →	+0.063	+4.467	<.001	.004	3	1
SKIN	OR5M11 →	+0.072	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PLA2G2E →	+0.339	+3.556	<.001	.007	3	1
LARGE_INTESTINE	CEACAM16 →	+0.105	+3.841	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR6K3 by KPNA3 expression — SKIN

Explore this box plot interactively →