KPNA2

Across TCGA patient cohorts, KPNA2 mutation is significantly associated with the RNA expression of many other genes, with 1,066 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPNA2-associated genes across cancer lineages are RNU6-1315P, MTCO1P51, and HMGN1P20. Each is linked with KPNA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA2-to-partner and partner-to-KPNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1315P grouped by KPNA2-low versus KPNA2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA2→partner) and Y-score (partner→KPNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-1315P →	+0.424	+4.126	.006	.005	3	2
CESC	MTCO1P51 →	+0.053	+5.418	<.001	.005	3	2
SKCM	HMGN1P20 →	+0.111	+3.186	<.001	.009	3	2
COAD	LINC01794 →	+0.135	+6.734	<.001	<.001	3	2
CESC	RN7SL350P →	+0.113	+5.010	.002	.009	3	2
LUAD	RNU6-952P →	+0.509	+4.631	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,066 associations by consensus.

RNU6-1315P by KPNA2 expression — BRCA

Explore this box plot interactively →