Across TCGA cell cohorts, KNTC1 mutation is significantly associated with the RNA expression of many other genes, with 466 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KNTC1-associated genes across cancer lineages are RABGGTB, TMEM107, and MAK16. Each is linked with KNTC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KNTC1-to-partner and partner-to-KNTC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNTC1→partner) and Y-score (partner→KNTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RABGGTB →	+0.804	+3.169	<.001	.009	3	2
LARGE_INTESTINE	TMEM107 →	+0.790	+3.502	.007	.001	3	2
LARGE_INTESTINE	MAK16 →	+0.839	+3.502	<.001	.001	3	2
SOFT_TISSUE	TBX22 →	+0.036	+5.369	<.001	.004	3	1
BREAST	CPN1 →	+0.996	+3.691	<.001	.009	3	1
LARGE_INTESTINE	POLR3G →	+1.411	+3.502	<.001	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 466 associations by consensus.

Exploration

KNTC1 survival (RNA) · tumor vs normal (RNA) · all KNTC1 data types