KNSTRN

Across TCGA pan-cancer cohorts, KNSTRN mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KNSTRN data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KNSTRN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KNSTRN expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, HNSC, and GBM are the cancer types where KNSTRN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.954	0.649	.011	8	view →
HNSC	OS	Quartile	All	0.809	0.973	.010	6	view →
GBM	OS	Quartile	All	0.614	0.252	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KNSTRN–LSCC (OS)

Open the LSCC breakdown →