KNSTRN

Across TCGA patient cohorts, KNSTRN mutation is significantly associated with the RNA expression of many other genes, with 1,114 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNSTRN-associated genes across cancer lineages are RNU4-71P, OR4D9, and RNA5-8SP2. Each is linked with KNSTRN in more than 1 cancer types. Because this analysis shows association rather than direction, both KNSTRN-to-partner and partner-to-KNSTRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-71P grouped by KNSTRN-low versus KNSTRN-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNSTRN→partner) and Y-score (partner→KNSTRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU4-71P →	+0.340	+6.711	<.001	<.001	3	2
SKCM	OR4D9 →	+0.030	+2.367	<.001	.001	3	2
SKCM	RNA5-8SP2 →	+0.096	+2.746	<.001	.001	3	2
SKCM	HBAP1 →	+0.023	+3.060	<.001	.005	3	2
UCEC	OIP5 →	+0.841	+2.721	.002	.003	3	2
UCEC	SLC66A2 →	+0.580	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,114 associations by consensus.

RNU4-71P by KNSTRN expression — BRCA

Explore this box plot interactively →