KNSTRN

Across TCGA patient cohorts, KNSTRN mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNSTRN-associated genes across cancer lineages are RAD51, Stathmin, and Cyclin-B1. Each is linked with KNSTRN in more than 1 cancer types. Because this analysis shows association rather than direction, both KNSTRN-to-partner and partner-to-KNSTRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by KNSTRN-low versus KNSTRN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNSTRN→partner) and Y-score (partner→KNSTRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.244	+3.321	<.001	.010	3	2
UCEC	Stathmin →	+0.216	+3.700	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.817	+3.321	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.289	-2.584	.013	.011	3	1
UCEC	ER-alpha →	-0.818	-2.986	.032	.035	3	1
UCEC	INPP4B →	-0.313	-2.321	.037	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

RAD51 by KNSTRN expression — UCEC

Explore this box plot interactively →