KNOP1P5

Across TCGA pan-cancer cohorts, KNOP1P5 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KNOP1P5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KNOP1P5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KNOP1P5 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

HNSC, BRCA, and KIRC are the cancer types where KNOP1P5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KNOP1P5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.043	<.001	8	view →
BRCA	Female	All	+0.212	.006	4	view →
KIRC	Male	II,III,IV	−0.025	.002	4	view →
LUSC	All	All	+0.408	<.001	2	view →
LIHC	All	All	+0.325	.004	2	view →
LUAD	All	All	+0.177	.012	2	view →
CHOL	Male	All	+0.160	.017	2	view →
COAD	All	All	+0.033	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

KNOP1P5–HNSC

Open the HNSC breakdown →