KNOP1P4

Across TCGA pan-cancer cohorts, KNOP1P4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KNOP1P4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KNOP1P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KNOP1P4 is over-expressed in tumor.

HNSC, LUSC, and KIRC are the cancer types where KNOP1P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KNOP1P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.060	<.001	10	view →
LUSC	All	II,III,IV	+0.086	<.001	8	view →
KIRC	All	IV	+0.016	.011	7	view →
COAD	All	III,IV	+0.060	.013	6	view →
LUAD	All	All	+0.051	<.001	5	view →
KICH	Female	III,IV	+0.036	<.001	5	view →
BRCA	All	All	+0.042	<.001	4	view →
BLCA	All	All	+0.023	.028	4	view →
KIRP	Female	All	+0.025	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

KNOP1P4–HNSC

Open the HNSC breakdown →