KNOP1

Across TCGA pan-cancer cohorts, KNOP1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KNOP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KNOP1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KNOP1 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

HNSC, LSCC, and CCRCC are the cancer types where KNOP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KNOP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.408	<.001	11	view →
LSCC	Female	All	+1.020	<.001	8	view →
CCRCC	Male	All	+0.717	<.001	8	view →
LUAD	Male	III,IV	+0.587	<.001	8	view →
COAD	All	All	+0.546	<.001	4	view →
PDAC	Male	All	−0.299	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KNOP1–HNSC

Open the HNSC breakdown →