KNL1

Across TCGA pan-cancer cohorts, KNL1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KNL1 data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KNL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KNL1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where KNL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.988	0.723	<.001	62	view →
LUAD	DFS	Tertile	All	0.591	0.941	.002	42	view →
PDAC	DFS	Median	III,IV	0.586	0.244	.001	14	view →
UCEC	DFS	Tertile	All	0.755	0.958	.025	6	view →
CCRCC	OS	Median	II,III,IV	0.689	1.000	.025	3	view →
HNSC	OS	Tertile	II,III,IV	1.000	0.945	.047	1	view →
GBM	OS	Tertile	All	0.734	0.863	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KNL1–LSCC (OS)

Open the LSCC breakdown →