KNL1

Across TCGA patient cohorts, KNL1 protein abundance is significantly associated with the RNA expression of many other genes, with 20,048 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KNL1-associated genes across cancer lineages are CDKN3, GINS1, and FAM83D. Each is linked with KNL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both KNL1-to-partner and partner-to-KNL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KNL1 versus CDKN3 in LUAD, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNL1→partner) and Y-score (partner→KNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDKN3 →	+1.052	+0.635	<.001	<.001	3	6
LUAD	GINS1 →	+1.098	+0.648	<.001	<.001	3	6
UCEC	FAM83D →	+1.127	+0.578	<.001	<.001	3	6
UCEC	CENPI →	+0.950	+0.438	<.001	<.001	3	6
UCEC	OIP5 →	+1.004	+0.702	<.001	<.001	3	6
LUAD	MCM4 →	+1.005	+0.702	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,048 associations by consensus.

KNL1 vs CDKN3 — LUAD

Explore this scatter interactively →