KNL1

Across TCGA patient cohorts, KNL1 mutation is significantly associated with the RNA expression of many other genes, with 5,098 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNL1-associated genes across cancer lineages are CDC25A, UQCRH, and RANBP1. Each is linked with KNL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KNL1-to-partner and partner-to-KNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC25A grouped by KNL1-low versus KNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNL1→partner) and Y-score (partner→KNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDC25A →	+0.529	+1.860	<.001	.001	3	4
UCEC	UQCRH →	+0.676	+1.523	.001	<.001	3	4
STAD	RANBP1 →	+0.621	+3.219	.004	.008	3	4
UCEC	CENPM →	+0.392	+1.595	.005	.005	3	4
UCEC	NCAPG →	+0.598	+2.403	<.001	<.001	3	4
UCEC	MRPL37 →	+0.446	+2.039	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,098 associations by consensus.

CDC25A by KNL1 expression — UCEC

Explore this box plot interactively →