KNL1

Across TCGA patient cohorts, KNL1 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNL1-associated genes across cancer lineages are TFRC, FoxM1, and JNK_pT183_Y185. Each is linked with KNL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KNL1-to-partner and partner-to-KNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by KNL1-low versus KNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNL1→partner) and Y-score (partner→KNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.380	+1.169	.012	.017	3	4
LUSC	FoxM1 →	+0.244	+2.124	.029	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.187	-1.723	<.001	<.001	3	2
LUSC	MSH6 →	+0.347	+1.594	.031	.043	3	2
LUSC	B-Raf →	+0.355	+3.013	.028	.018	3	2
LUSC	C-Raf_pS338 →	-0.086	-3.169	.040	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

TFRC by KNL1 expression — UCEC

Explore this box plot interactively →