KNL1

Across TCGA cell cohorts, KNL1 mutation is significantly associated with the RNA expression of many other genes, with 808 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KNL1-associated genes across cancer lineages are TCP10L3, PSKH2, and SSX3. Each is linked with KNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KNL1-to-partner and partner-to-KNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP10L3 grouped by KNL1-low versus KNL1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNL1→partner) and Y-score (partner→KNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TCP10L3 →	+0.013	+5.000	<.001	.005	3	2
LUNG_NSCLC_LUAD	PSKH2 →	+0.020	+3.887	<.001	.002	3	2
LUNG_NSCLC_LUAD	SSX3 →	+1.101	+4.415	<.001	<.001	3	2
SKIN	C1QC →	+0.025	+4.196	<.001	.002	3	2
CNS	OR5A1 →	+0.521	+3.566	<.001	.003	3	2
CNS	NLRP13 →	+0.011	+3.145	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 808 associations by consensus.

TCP10L3 by KNL1 expression — KIDNEY

Explore this box plot interactively →