KNDC1

Across TCGA patient cohorts, KNDC1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNDC1-associated genes across cancer lineages are PKC-delta_pS664, ATM, and Caspase-7-cleavedD198. Each is linked with KNDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KNDC1-to-partner and partner-to-KNDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by KNDC1-low versus KNDC1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNDC1→partner) and Y-score (partner→KNDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PKC-delta_pS664 →	-0.170	-2.984	.003	.034	3	3
COAD	ATM →	-0.357	-1.576	.009	.035	3	3
COAD	Caspase-7-cleavedD198 →	+0.713	+2.008	.010	.005	3	3
LUSC	Dvl3 →	-0.295	-3.000	<.001	.035	2	3
STAD	Caveolin-1 →	-0.662	-3.169	.043	.018	3	2
COAD	ERK2 →	+0.166	+3.000	.015	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PKC-delta_pS664 by KNDC1 expression — STAD

Explore this box plot interactively →