KNDC1

Across TCGA cell cohorts, KNDC1 mutation is significantly associated with the RNA expression of many other genes, with 415 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KNDC1-associated genes across cancer lineages are HAUS1, MAK16, and NKX2-8. Each is linked with KNDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KNDC1-to-partner and partner-to-KNDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS1 grouped by KNDC1-low versus KNDC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNDC1→partner) and Y-score (partner→KNDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HAUS1 →	+0.720	+2.129	<.001	.007	3	3
LARGE_INTESTINE	MAK16 →	+0.693	+2.043	.003	.008	3	3
BLOOD_Myeloma	NKX2-8 →	+0.068	+3.906	.005	.009	3	2
OVARY	PPY →	+0.201	+4.029	<.001	.009	3	2
LARGE_INTESTINE	MED31 →	+0.543	+2.743	.006	.001	2	3
LARGE_INTESTINE	GCH1 →	+0.631	+2.743	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 415 associations by consensus.

HAUS1 by KNDC1 expression — LARGE_INTESTINE

Explore this box plot interactively →