KMT5AP1

Across TCGA pan-cancer cohorts, KMT5AP1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated KMT5AP1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher KMT5AP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KMT5AP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

MESO, ACC, and KICH are the cancer types where KMT5AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.264	0.447	.001	74	view →
ACC	OS	Median	All	0.382	0.790	<.001	74	view →
KICH	DFS	Tertile	III,IV	0.188	0.860	.008	48	view →
HNSC	DFS	Median	II,III,IV	0.688	0.526	.001	37	view →
UVM	DFS	Quartile	III,IV	0.301	0.820	<.001	30	view →
UCS	DFS	Tertile	IV	0.932	0.361	.024	24	view →
KIRP	OS	Quartile	All	0.893	0.987	.005	18	view →
BRCA	OS	Median	III,IV	0.664	0.429	.005	15	view →
STAD	DFS	Tertile	II,III,IV	0.216	0.463	.018	14	view →
KIRC	DFS	Median	III,IV	0.756	0.509	.004	12	view →
THCA	OS	Quartile	III,IV	1.000	0.890	.012	10	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

KMT5AP1–MESO (DFS)

Open the MESO breakdown →