KMT2D

Across TCGA patient cohorts, KMT2D RNA expression is significantly associated with the protein abundance of many other proteins, with 10,131 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KMT2D-associated proteins across cancer lineages are MAST2_S92, TNS2_S835, and MYG1. Each is linked with KMT2D in more than 3 cancer types. Because this analysis shows association rather than direction, both KMT2D-to-partner and partner-to-KMT2D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KMT2D versus MAST2_S92 in LUAD, with a Pearson correlation of -0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2D→partner) and Y-score (partner→KMT2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAST2_S92 →	-0.621	-0.671	.001	<.001	3	4
LUAD	TNS2_S835 →	-0.426	-0.426	<.001	<.001	3	3
HNSC	MYG1 →	+0.265	+0.948	<.001	<.001	3	3
LSCC	NAB2 →	+0.322	+0.472	.003	.001	3	3
LSCC	RINT1 →	-0.160	-0.551	<.001	<.001	3	3
LSCC	UTP18_S205 →	+0.515	+0.599	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,131 associations by consensus.

KMT2D vs MAST2_S92 — LUAD

Explore this scatter interactively →