KMT2D

Across TCGA patient cohorts, KMT2D protein abundance is significantly associated with the RNA expression of many other genes, with 6,792 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible KMT2D-associated genes across cancer lineages are ATP5MC2, JPH2, and GJB2. Each is linked with KMT2D in more than 4 cancer types. Because this analysis shows association rather than direction, both KMT2D-to-partner and partner-to-KMT2D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KMT2D versus ATP5MC2 in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2D→partner) and Y-score (partner→KMT2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ATP5MC2 →	+0.665	+0.304	<.001	<.001	3	4
HNSC	JPH2 →	-0.671	-0.179	.007	.004	2	5
OV	GJB2 →	-2.013	-0.279	.002	.005	2	5
LSCC	HIP1R →	+0.484	+0.197	<.001	<.001	3	4
PDAC	SLC39A5 →	+1.274	+0.171	.001	.004	3	4
BRCA	SPATS2L →	-0.754	-0.235	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,792 associations by consensus.

KMT2D vs ATP5MC2 — OV

Explore this scatter interactively →