KMT2D

Across TCGA patient cohorts, KMT2D mutation is significantly associated with the RNA expression of many other genes, with 12,274 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT2D-associated genes across cancer lineages are SHMT2, IL34, and SHROOM4. Each is linked with KMT2D in more than 7 cancer types. Because this analysis shows association rather than direction, both KMT2D-to-partner and partner-to-KMT2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHMT2 grouped by KMT2D-low versus KMT2D-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2D→partner) and Y-score (partner→KMT2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SHMT2 →	+0.488	+2.067	<.001	<.001	3	8
STAD	IL34 →	-0.714	-2.983	<.001	<.001	3	8
COAD	SHROOM4 →	-0.949	-1.601	<.001	<.001	3	8
SKCM	CCDC59 →	+0.307	+1.713	.003	<.001	3	7
STAD	CCNB1 →	+0.745	+2.115	<.001	<.001	3	7
STAD	BAG4 →	+0.520	+2.502	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,274 associations by consensus.

SHMT2 by KMT2D expression — HNSC

Explore this box plot interactively →