KMT2D

Across TCGA patient cohorts, KMT2D mutation is significantly associated with the total protein of many other genes, with 111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT2D-associated genes across cancer lineages are Cyclin-B1, GAPDH, and Caveolin-1. Each is linked with KMT2D in more than 4 cancer types. Because this analysis shows association rather than direction, both KMT2D-to-partner and partner-to-KMT2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by KMT2D-low versus KMT2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2D→partner) and Y-score (partner→KMT2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.420	+1.807	<.001	<.001	3	5
COAD	GAPDH →	+0.583	+1.745	<.001	<.001	3	5
STAD	Caveolin-1 →	-0.681	-1.807	.005	.023	3	4
COAD	Cyclin-E2 →	+0.259	+1.465	<.001	.012	3	4
CESC	Bak →	+0.091	+1.495	.018	.048	3	4
UCEC	eEF2 →	+0.264	+1.121	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 111 associations by consensus.

Cyclin-B1 by KMT2D expression — UCEC

Explore this box plot interactively →