KMT2D

Across TCGA cell cohorts, KMT2D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,948 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KMT2D-associated GO terms across cancer lineages are Oocyte growth, Negative regulation of chromosome condensation, and Epigenetic regulation of gene expression. Each is linked with KMT2D in more than 19 cancer types. Because this analysis shows association rather than direction, both KMT2D-to-partner and partner-to-KMT2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oocyte growth grouped by KMT2D-low versus KMT2D-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2D→partner) and Y-score (partner→KMT2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Oocyte growth →	+0.300	+1.295	<.001	<.001	3	20
STOMACH	Negative regulation of chromosome condensation →	+0.187	+1.539	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.074	+1.293	<.001	<.001	3	18
OVARY	Negative regulation of DNA-templated transcription, elongation →	+0.107	+0.890	<.001	<.001	3	18
URINARY_TRACT	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.182	+1.347	<.001	<.001	3	18
STOMACH	Negative regulation of transcription by RNA polymerase III →	+0.166	+1.128	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,948 associations by consensus.

Oocyte growth by KMT2D expression — URINARY_TRACT

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