KLRF1

Across TCGA cell cohorts, KLRF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,126 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible KLRF1-associated GO terms across cancer lineages are Proteasomal ubiquitin-independent protein catabolic process, Negative regulation of response to biotic stimulus, and Intracellular distribution of mitochondria. Each is linked with KLRF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLRF1-to-partner and partner-to-KLRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proteasomal ubiquitin-independent protein catabolic process grouped by KLRF1-low versus KLRF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLRF1→partner) and Y-score (partner→KLRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Proteasomal ubiquitin-independent protein catabolic process →	+0.091	+0.503	<.001	.005	3	5
SOFT_TISSUE	Negative regulation of response to biotic stimulus →	+0.054	+0.067	.004	.004	3	4
SOFT_TISSUE	Intracellular distribution of mitochondria →	-0.125	-0.099	<.001	.007	3	4
SOFT_TISSUE	Process utilizing autophagic mechanism →	+0.047	+0.085	<.001	.005	3	4
SOFT_TISSUE	Autophagy →	+0.047	+0.085	<.001	.005	3	4
OVARY	Regionalization →	-0.027	-0.574	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,126 associations by consensus.

Proteasomal ubiquitin-independent protein catabolic process by KLRF1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →