Across TCGA pan-cancer cohorts, KLRC4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KLRC4 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher KLRC4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLRC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, BLCA, and UCS are the cancer types where KLRC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.078	0.536	<.001	18	view →
BLCA	DFS	Median	All	0.114	0.625	.025	12	view →
UCS	OS	Median	All	0.153	0.687	.019	6	view →
UCEC	OS	Median	All	1.000	0.654	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KLRC4 tumor-vs-normal RNA expression · all KLRC4 data types